NMN – Longevity, Performance & Obesity Research (60 Capsules) (5-Amino-1MQ, NMN, JBSNF)

5-amino-1MQ is a small molecule that blocks the activity of the enzyme called nicotinamide N-methyltransferase (NNMT). By blocking NNMT, 5-amino-1MQ stimulates an increase in NAD+, a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1). SIRT1 is also known as the “longevity gene” because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.

NMN (Nicotinamide mononucleotide) Nicotinamide mononucleotide (NMN) is a unique form of vitamin B3 that gets converted into Nicotinamide Adenine Dinucleotide (NAD+). NAD+ declines with age and is an essential coenzyme for a number of enzymes involved with energy production and cellular repair. The sirtuin family are among these NAD+ dependent enzymes and act as master switches of metabolism and regulators of aging. Preliminary research suggests NMN supports synthesis of NAD+ in tissues, supporting cellular function and longevity, energy metabolism, aerobic capacity and glucose homeostasis. Research has shown NMN to decrease age-associated body weight gain, improve energy metabolism, insulin sensitivity and plasma lipid profile, enhanced eye function and other pathophysiologies.

JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease. In mice with high fat diet (HFD)-induced obesity, JBSNF-000088 caused a reduction in body weight, improved insulin sensitivity and normalized glucose tolerance to the level of lean control mice.

These three compounds affect everything from energy metabolism to cellular performance and aging. They primarily by affecting levels of NAD, the expression of GLUT-4 receptors, the activity of the NNMT enzyme and the production of molecules known as sirtuins. By increasing levels of NAD and decreasing the activity of NNMT, these molecules work together to improve cellular metabolism, enhance weight loss, and improve glucose control. Further benefits of the synergy between these compounds are seen in cellular aging, where increased levels of NAD help stem cells to survive and thrive. This provides a pool of healthy cells that can readily take the place of those that are worn or damaged, leading to improved tissue function and decreasing the effects of aging. By combining these three compounds, it might be possible to drastically alter energy metabolism for the better while simultaneously boosting anti-aging, anti-inflammatory, and anti-apoptosis activity in cells.